Gene information
Official symbol MMP2
Official full name matrix metallopeptidase 2
Gene type protein-coding gene
Chromosome16q12.2
Alias symbolTBE-1
Previous symbolCLG4; CLG4A
Gene familyM10 matrix metallopeptidases
Resources
Entrez Gene 4313
HGNC HGNC:7166
Ensembl ENSG00000087245
Vega OTTHUMG00000133202
UCSC uc002ehz.5
GO terms: 148 records
GO Description Category LogP Number of genes Detail
GO:0000302 response to reactive oxygen species GO Biological Processes -13.4775134 34 More
GO:0001101 response to acid chemical GO Biological Processes -10.2965313 26 More
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001542 ovulation from ovarian follicle GO Biological Processes -7.26236298 5 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001704 formation of primary germ layer GO Biological Processes -8.70692533 22 More
GO:0001706 endoderm formation GO Biological Processes -7.82381493 14 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0001968 fibronectin binding GO Molecular Functions -9.79576986 9 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004222 metalloendopeptidase activity GO Molecular Functions -10.6700212 15 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0007162 negative regulation of cell adhesion GO Biological Processes -21.5212108 58 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007276 gamete generation GO Biological Processes -2.03816629 18 More
GO:0007292 female gamete generation GO Biological Processes -4.09618363 9 More
GO:0007369 gastrulation GO Biological Processes -9.78060849 28 More
GO:0007492 endoderm development GO Biological Processes -8.07123392 17 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007548 sex differentiation GO Biological Processes -7.13021119 33 More
GO:0007565 female pregnancy GO Biological Processes -18.4002911 25 More
GO:0007566 embryo implantation GO Biological Processes -9.99023740 10 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008237 metallopeptidase activity GO Molecular Functions -10.3008607 18 More
GO:0008406 gonad development GO Biological Processes -5.85435513 14 More
GO:0008585 female gonad development GO Biological Processes -5.58425106 9 More
GO:0009314 response to radiation GO Biological Processes -9.77450393 26 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009411 response to UV GO Biological Processes -7.07745319 13 More
GO:0009416 response to light stimulus GO Biological Processes -4.81054429 15 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010171 body morphogenesis GO Biological Processes -1.81403430 3 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0014823 response to activity GO Biological Processes -19.5783025 27 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019229 regulation of vasoconstriction GO Biological Processes -25.9471687 22 More
GO:0021700 developmental maturation GO Biological Processes -12.5205714 23 More
GO:0022411 cellular component disassembly GO Biological Processes -6.34931814 17 More
GO:0022602 ovulation cycle process GO Biological Processes -5.5402655 7 More
GO:0022612 gland morphogenesis GO Biological Processes -7.35048069 19 More
GO:0022617 extracellular matrix disassembly GO Biological Processes -9.45487411 10 More
GO:0030016 myofibril GO Cellular Components -10.5185909 20 More
GO:0030017 sarcomere GO Cellular Components -8.52596130 17 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030574 collagen catabolic process GO Biological Processes -13.3732998 12 More
GO:0030728 ovulation GO Biological Processes -8.85891522 7 More
GO:0030850 prostate gland development GO Biological Processes -4.21089449 9 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031099 regeneration GO Biological Processes -17.4553316 23 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0032526 response to retinoic acid GO Biological Processes -5.75287026 10 More
GO:0032963 collagen metabolic process GO Biological Processes -15.1142156 15 More
GO:0034405 response to fluid shear stress GO Biological Processes -8.30035543 8 More
GO:0034599 cellular response to oxidative stress GO Biological Processes -11.6255265 36 More
GO:0034614 cellular response to reactive oxygen species GO Biological Processes -9.93259803 24 More
GO:0034644 cellular response to UV GO Biological Processes -5.54644403 9 More
GO:0035094 response to nicotine GO Biological Processes -8.07167727 14 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0035987 endodermal cell differentiation GO Biological Processes -8.15231722 13 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0036296 response to increased oxygen levels GO Biological Processes -6.18749803 9 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042542 response to hydrogen peroxide GO Biological Processes -8.84445919 13 More
GO:0042698 ovulation cycle GO Biological Processes -6.53718605 9 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043200 response to amino acid GO Biological Processes -9.16129691 23 More
GO:0043292 contractile fiber GO Cellular Components -11.9705216 22 More
GO:0043627 response to estrogen GO Biological Processes -7.69647850 16 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044703 multi-organism reproductive process GO Biological Processes -20.5752550 28 More
GO:0044706 multi-multicellular organism process GO Biological Processes -20.0155761 28 More
GO:0045137 development of primary sexual characteristics GO Biological Processes -5.73912217 14 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0045906 negative regulation of vasoconstriction GO Biological Processes -5.18389496 5 More
GO:0046545 development of primary female sexual characteristics GO Biological Processes -5.43927805 9 More
GO:0046660 female sex differentiation GO Biological Processes -6.37740711 11 More
GO:0048511 rhythmic process GO Biological Processes -10.3377021 38 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0048678 response to axon injury GO Biological Processes -4.04506120 6 More
GO:0048705 skeletal system morphogenesis GO Biological Processes -7.04838258 29 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051602 response to electrical stimulus GO Biological Processes -5.14667380 10 More
GO:0055093 response to hyperoxia GO Biological Processes -7.60090654 9 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060323 head morphogenesis GO Biological Processes -2.0068648 3 More
GO:0060324 face development GO Biological Processes -1.60392838 3 More
GO:0060325 face morphogenesis GO Biological Processes -2.15864942 3 More
GO:0060343 trabecula formation GO Biological Processes -3.52782140 6 More
GO:0060512 prostate gland morphogenesis GO Biological Processes -4.25041921 7 More
GO:0060740 prostate gland epithelium morphogenesis GO Biological Processes -4.51081372 7 More
GO:0061383 trabecula morphogenesis GO Biological Processes -5.83082467 11 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0070141 response to UV-A GO Biological Processes -7.87763977 6 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070555 response to interleukin-1 GO Biological Processes -18.9736890 36 More
GO:0071214 cellular response to abiotic stimulus GO Biological Processes -11.2775864 23 More
GO:0071229 cellular response to acid chemical GO Biological Processes -7.57719972 18 More
GO:0071230 cellular response to amino acid stimulus GO Biological Processes -6.04975320 15 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071347 cellular response to interleukin-1 GO Biological Processes -16.1002741 19 More
GO:0071392 cellular response to estradiol stimulus GO Biological Processes -5.13834229 6 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071478 cellular response to radiation GO Biological Processes -4.2266687 10 More
GO:0071482 cellular response to light stimulus GO Biological Processes -4.67282705 9 More
GO:0071492 cellular response to UV-A GO Biological Processes -8.67610245 6 More
GO:0071695 anatomical structure maturation GO Biological Processes -11.1692541 20 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0104004 cellular response to environmental stimulus GO Biological Processes -11.2775864 23 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1904645 response to amyloid-beta GO Biological Processes -11.2505232 12 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 10 records
KEGG Description Category LogP Number of genes Detail
hsa01522 Endocrine resistance KEGG Pathway -4.64858532 8 More
hsa04670 Leukocyte transendothelial migration KEGG Pathway -6.49203386 11 More
hsa04915 Estrogen signaling pathway KEGG Pathway -2.87451539 7 More
hsa04926 Relaxin signaling pathway KEGG Pathway -10.8215200 16 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
hsa05219 Bladder cancer KEGG Pathway -8.60591296 9 More
hsa05415 Diabetic cardiomyopathy KEGG Pathway -11.4800633 20 More
hsa05418 Fluid shear stress and atherosclerosis KEGG Pathway -23.1665561 27 More
Drug-Gene interaction
view
Related drugs: 24 records
Drug name Interaction type Source PMID View
acetazolamide DTC 24074025 view
aldesleukin NCI 8938794 view
bevacizumab CIViC 26921265 view
chlorhexidine NCI 10225852 view
cyclosporine NCI 12639820 view
deferoxamine DTC 24074025 view
demethylwedelolactone DTC 22926226 view
filgrastim NCI 11391619 view
incyclinide TdgClinicalTrialTTD view
letrozole NCI 12569569 view
marimastat inhibitor TdgClinicalTrialTENDTTD 157488941046064211790786117523521252792315056115 view
obovatal DTC 17428670 view
paclitaxel NCI 9174131 view
perfosfamide NCI 17046572 view
pravastatin NCI 15842807 view
prinomastat vaccine TALCTTD view
ramipril NCI 16166267 view
rebimastat NCI 15041713 view
resveratrol NCI 16084059 view
s-3304 vaccine TALC view
simvastatin NCI 16436088 view
streptozocin NCI 9394952 view
vinblastine NCI 10590059 view
zileuton DTC 24074025 view
Related studies: 16 records
Molecular factor Omics type Application Objective MI type Reference
MMP2 transcriptomics cerebral infarction[prognosis (bad)] acute myocardial infarction Zhou L et al. Eur Rev Med Pharmacol Sci. 2019
72 kDa type IV collagenase proteomics left ventricular dysfunction[prognosis (bad)] acute myocardial infarction Nakaya R et al. Int J Cardiol. 2005
72 kDa type IV collagenase proteomics pravastatin[treatment (pharmacotherapy)] acute myocardial infarction Nakaya R et al. Int J Cardiol. 2005
72 kDa type IV collagenase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Nakaya R et al. Int J Cardiol. 2005
72 kDa type IV collagenase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kameda K et al. Circ J. 2006
72 kDa type IV collagenase proteomics statin[treatment (pharmacotherapy)] acute myocardial infarction Yasuda S et al. Clin Sci (Lond). 2007
72 kDa type IV collagenase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Hlatky MA et al. Am Heart J. 2007
72 kDa type IV collagenase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Dai F et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
72 kDa type IV collagenase proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Nie R et al. Arch Med Res. 2009
72 kDa type IV collagenase proteomics infarct size[other] ST elevation myocardial infarction Nilsson L et al. Heart. 2012
72 kDa type IV collagenase proteomics left ventricular remodeling[prognosis (bad)] acute anterior myocardial infarction Cogni AL et al. Arq Bras Cardiol. 2013
72 kDa type IV collagenase proteomics good predictor left ventricular reverse remodeling[prognosis (good)] acute myocardial infarction Morishita T et al. J Am Heart Assoc. 2015
72 kDa type IV collagenase proteomics cerebral infarction[prognosis (bad)] acute myocardial infarction Zhou L et al. Eur Rev Med Pharmacol Sci. 2019
NM_001127891.3:c.-1306C>T genomics myocardial infarction[diagnosis] myocardial infarction Delgado-Enciso I et al. J Genet. 2009
NM_001127891.3:c.-735C>T genomics myocardial infarction[diagnosis] myocardial infarction Alp E et al. Genet Test Mol Biomarkers. 2011
NM_001127891.3:c.-1575G>A genomics myocardial infarction[diagnosis] myocardial infarction Perez-Hernandez N et al. J Atheroscler Thromb. 2012
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